This happens most to belly fat cells, but whenever fat cells get filled with fat, they begin to lose their sensitivity to insulin. The more they get filled up the more resistant they get. There is an FSM protocol to treat this that seems to help. And I have even made a remedy out of it that also seems to help some. FSM also has a protocol to help the pancreas produce more insulin. I have used the pancreas protocol and the remedy for the Insulin Resistance protocol together on a friend of mine and lowered his A1C a whole point and brought him from barely diabetic to non-diabetic. So they do seem to work.